One of the most common methods for creating a sterile bioprocessing environment is the use of heat in the form of steam to eliminate unwanted organisms. Steam-In-Place (SIP) is a good sterilization method and involves sterilizing by means of steam the interior of pipes, vessels, process equipment, and associated fittings, without disassembly.
Steam-in-Place (SIP) can be a critical element in any startup and commissioning project. However, the full range of SIP strategies are not always thoroughly understood, and thus many manufacturers miss important elements of these techniques.
To know more about the application of SIP, about • Bioburden reduction• Saturated steam conditions: Temperature/pressure relationship• Autoclaves, vessels, filters and transfer lines• Empty- and full-vessel SIP• Proper use of Tempilstik®
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Effective Steam-in-Place Strategies to Consider before Qualifying a Facility